Among patients with type 2 diabetes (T2D), high mean platelet volume was independently associated with metabolic syndrome. These findings appear in a recent issue of the journal Medicine.

Elevated mean platelet volume levels have been presumed to be linked to metabolic disorders and cardiovascular diseases, although a causative relationship has never before been proven. In this study, researchers from China evaluated the relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus and for the first time, document an independent association between the two conditions in T2D, particularly in male patients who are overweight, are older or have poor glycemic control.

The study, which was conducted between 2017 and 2020, included 1,240 patients (mean age 53 years, 64% men) with T2D. For the purposes of this study, the metabolic syndrome was defined as abdominal obesity of³90 cm for men and ³85 cm for women; having elevated blood pressure of ³130 mmHg systolic pressure or ³85 mmHg diastolic pressure; a hypertriglyceridemia of ³1.7 mmol/L); low high-density lipoprotein cholesterol of <1.04 mmol/L; and, hyperglycemia with a fasting glucose of ³6.01 mmol/L and a 2-hour postprandial glucose of ³7.8 mmol/L.

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Patients with metabolic syndrome (n=873) were more likely to be men (P =.007) who smoked (P =.001), consumed alcohol (P =.003), had increased BMI (P <.001) and increased waist circumference (P <.001), hypertension (P <.001), and systolic (P <.001) and diastolic (P <.001) blood pressure. They also had a high red blood cell count (P <.001). , Mean platelet volume (P <.001), triglyceride (P <.001), fasting C-peptide (P <.001), homeostasis model assessment of insulin resistance (HOMA-IR; P <.001), but decreased HDL-C (P <.001) as compared to control group.

Significant correlations were observed between mean platelet volume and waist circumference (r, 0.151; P <.001), HOMA-IR (r, 0.081; P =.005), and triglycerides (r, 0.082; P =.005). Increased risk for metabolic syndrome were associated with BMI (odds ratio [OR], 1.422; 95% CI, 1.346-1.502) and MPV (OR, 1.174; 95% CI, 1.059-1.302).

Among patients in the highest tertile of mean platelet volume, , normal BMI (24-28 kg/m2; adjusted OR [aOR], 2.998; 95% CI, 1.428-6.294; P =.004), high glycated hemoglobin (³9%; aOR, 2.361; 95% CI, 1.374-4.061; P =-002), increased age (³60 years; aOR, 1.923; 95% CI, 1.083-3.416; P =.020), and male gender (aOR, 1.674; 95% CI, 1.022-2.741; P =.041) were associated with increased risk for metabolic syndrome.

In terms of study limitations, the study was conducted among in-hospital patients with T2D and these results may not be generalizable to other study populations.


Ding Q, Wang F, Guo X, Liang M. The relationship between mean platelet volume and metabolic syndrome in patients with type 2 diabetes mellitus: A retrospective study. Medicine. 2021;100(13):e25303. doi:10.1097/MD.0000000000025303.