(HealthDay News) — For men, but not women, with type 2 diabetes, a 4-year weight loss intervention is associated with a small, but significant increase in bone loss, according to a study published online in Diabetes Care.
Edward W. Lipkin, MD, PhD, from the VA Puget Sound Health Care System and University of Washington in Seattle, and colleagues examined the long-term impact of a randomized trial of intensive weight loss on bone mineral density (BMD).
The trial randomly assigned 1,309 overweight and obese individuals with type 2 diabetes to an intensive lifestyle intervention vs. a diabetes support and education intervention. The researchers assessed BMD at baseline and after 1 and 4 years of intervention.
The researchers found that, compared with the diabetes support and education intervention, the intensive lifestyle intervention produced significant weight loss (5.3% vs. 1.8%; P<.01) and increased fitness (6.4% vs. −0.8%) at year 4.
During the first year, men in the intensive lifestyle intervention group had a greater rate of bone loss than those in the diabetes support and education intervention group (−1.66% vs. −0.09% per year). The between-group difference was attenuated after 4 years, but remained significant (−0.88% vs. −0.05% per year; P<.01).
Over 4 years, the between-group difference in the rate of hip bone loss was related to increased weight loss in the intensive lifestyle intervention group. After 4 years, there was no between-group difference in the rate of bone loss for women.
“A 4-year weight loss intervention was significantly associated with a modest increase in bone loss at the hip in men but not in women,” the researchers wrote.
Several pharmaceutical and nutrition companies provided funding for the Look AHEAD Trial.