Does PCOS Increase T2D Event Rate?

HealthDay News — Women with polycystic ovary syndrome (PCOS) have a higher event rate of type 2 diabetes (T2D), with diagnosis at a younger age, according to a study published online in the Journal of Clinical Endocrinology & Metabolism.

Katrine Hass Rubin, PhD, from the University of Southern Denmark in Odense, and colleagues conducted a national register-based study involving patients with PCOS (PCOS Denmark and embedded cohort [PCOS OUH]) and a control population without T2D. A total of 1162 premenopausal women were included in PCOS OUH, while PCOS Denmark included 18,477 women with PCOS; 3 age-matched controls were included for each woman (54,680).

The researchers found that during a median follow-up of 11.1 years, the hazard ratio for development of T2D was 4.0 in PCOS Denmark, with a total event rate of 8 versus 2 per 1000 patient years in PCOS Denmark versus controls. The median age at diagnosis of T2D was 31 and 35 years in PCOS Denmark and controls, respectively. Positive associations were seen for BMI, HbA1c, fasting blood glucose, 2-hour blood glucose, homeostasis model assessment of insulin resistance, and triglycerides with T2D; a negative association was seen for higher number of births with T2D.

“The event rate of T2D was higher in PCOS compared to controls and T2D was diagnosed at a younger age,” the authors write.

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Haas Rubin K, Glintborg D, Nybo M, Abrahamsen B, Andersen M. Development and risk factors of type 2 diabetes in a nationwide population of women with polycystic ovary syndrome [published online August 29, 2017]. J Clin Endocinol Metab. doi:10.1210/jc.2017-01354