Coronary Heart Disease Risk in Diabetes Tied to Earlier BMI

(HealthDay News) — The risk for coronary heart disease (CHD) over 7 years increases with higher BMI at baseline among patients with diabetes, with a U-shaped association between BMI at the last visit and the risk for CHD among women, according to a study published in Diabetes Care.

Nan Li, MD, from Pennington Biomedical Research Center in Baton Rouge, Louisiana, and colleagues investigated the association between BMI and CHD risk among type 2 diabetes patients (10,955 men and 19,479 women) aged 30 to 95 years. Participants were free of CHD and stroke at baseline.

During a mean follow-up of 7.3 years, 7,414 subjects developed CHD. Across BMI levels (18.5 to 24.9, 25 to 29.9, 30 to 34.9, 35 to 39.9 and ≥40) at baseline, the multivariable-adjusted hazard ratios (HRs) for CHD were 1.00, 1.14 (95% CI, 1.00-1.29), 1.27 (95% CI, 1.12-1.45), 1.54 (95% CI, 1.34-1.78) and 1.42 (95% CI, 1.23-1.64) in men.

In women, HRs were 1.00, 0.95 (95% CI, 0.85-1.07), 0.95 (95% CI, 0.84-1.06), 1.06 (95% CI, 0.94-1.2) and 1.09 (95% CI, 1.00-1.22), respectively.

The positive association between BMI and CHD risk did not change in men when the researchers used a mean or last-visit BMI value. In women, however, with use of the last-visit value of BMI, the positive association of BMI with CHD changed to a U-shaped association.

“Our study suggests that there is a positive association between BMI at baseline and during follow-up with the risk of CHD among patients with type 2 diabetes,” concluded the researchers.


  1. Li N et al. Diabetes Care. 2014;doi:10.2337/dc14-1091.