(HealthDay News) — The risk for colorectal cancer is moderately increased in patients with type 2 diabetes, according to research published in Diabetes Care.

Paul J.H.L. Peeters, of the Utrecht University in the Netherlands, and colleagues conducted an observational population-based cohort study in which 300,039 patients, aged 18 years or older, with at least one prescription for an antidiabetic drug, were matched with a comparison cohort of individuals without diabetes. The risk for colorectal cancer associated with type 2 diabetes was assessed.

The researchers found, at a median follow-up of 4.5 years, 2,759 cases of colorectal cancer in patients with diabetes. Type 2 diabetes was associated with increased risk for colorectal cancer (HR=1.26; 95% CI, 1.18-1.33). 


Continue Reading

No association was found between risk for colorectal cancer and treatment stages for diabetes. Risk for colorectal cancer was significantly higher in patients with documented duration of obesity of 4 to 8 years (HR=1.19; 95% CI, 1.06-1.34) and longer than 8 years (HR=1.28; 95% CI, 1.11-1.49).

“In summary, we observed a moderate, yet (1.3-fold) significantly increased, risk of colorectal cancer in patients treated for type 2 diabetes,” the researchers wrote.

One author conducts research coordinated by an institution that receives funding partly from pharmaceutical companies.

Reference

  1. Peeters PJHL et al. Diabetes Care. 2014;doi:10.2337/dc14-1175.