Cognitive Status in T2D: Retinal Sensitivity Predictive of Neurodegeneration

HealthDay News — In patients with type 2 diabetes, retinal sensitivity is associated with cognitive status, according to a study published in Diabetes.

Andreea Ciudin, from the Universitat Autònoma de Barcelona in Spain, and colleagues conducted a prospective nested case-control study including 105 patients with type 2 diabetes — 35 without cognitive impairment, 35 with mild cognitive impairment (MCI), and 35 with Alzheimer’s disease (AD). Magnetic resonance imaging (MRI) and 18FDG-positron emission tomography (PET) were used to assess brain neurodegeneration.

The researchers identified a significant correlation between retinal sensitivity assessed by microperimetry and the MRI and 18FDG-PET parameters found to be related to brain neurodegeneration. There was a correlation between retinal sensitivity and cognitive status (normocognitive > MCI > AD; P <.001).

“Our results suggest that retinal sensitivity assessed by microperimetry is related to brain neurodegeneration and could be a useful biomarker for identifying type 2 diabetes patients at risk of developing AD,” the authors write.

Related Articles


Ciudin A, Simo-Servat O, Hernandez C, et al. Retinal microperimetry: a new tool for identifying type 2 diabetic patients at risk of developing Alzheimer’s disease [published online September 26, 2017]. Diabetes. doi:10.2337/db17-0382