(HealthDay News) — For individuals at high cardiovascular (CV) risk, serum calcium concentrations correlate with increased diabetes risk, according to research published in Diabetes Care.
Nerea Becerra-Tomás, from Universitat Rovira i Virgili in Rues, Spain, and colleagues conducted a prospective assessment to examine the correlation between albumin-adjusted serum calcium concentrations and type 2 diabetes in individuals at high CV risk.
Data were included for participants from two Spanish PREDIMED (Prevención con Dieta Mediterránea) study centers.
After a median follow-up of 4.78 years, the researchers identified 77 new cases of type 2 diabetes. Increased risk for diabetes was seen in association with an increase in serum calcium levels during follow-up.
The hazard ratio for diabetes incidence during follow-up was 3.48 for those in the highest tertile of change vs. the lowest tertile (P for trend=.01). On analysis of albumin-adjusted serum calcium as a continuous variable, the hazard ratio for diabetes incidence was 2.87 per 1 mg/dL increase (P=.02).
The association persisted after exclusion of those taking calcium supplements or those with calcium levels out of the normal range.
“An increase in serum calcium concentrations is associated with an increased risk of type 2 diabetes in individuals at high cardiovascular risk,” the researchers wrote.