(HealthDay News) — For women with gestational diabetes, baseline and most recent BMI and weight gain after gestational diabetes correlate with increased long-term risk for developing type 2 diabetes, according to a study published in Diabetologia.
Wei Bao, MD, PhD, from the National Institutes of Health in Rockville, Maryland, and colleagues examined how adiposity and weight change influence the long-term risk for developing type 2 diabetes after gestational diabetes. Data were included for 1,695 women with incident gestational diabetes between 1991 and 2001.
During 18 years of follow-up, the researchers identified 259 incident cases of type 2 diabetes. For each 1-kg/m² increase in BMI, the adjusted hazard ratio (HR) for type 2 diabetes was 1.16 for baseline BMI and 1.16 for most recent BMI.
Each 5-kg increment of weight gain after gestational diabetes development correlated with an increased risk for type 2 diabetes (adjusted HR=1.27). Compared with women who had a BMI of <25 kg/m² and gained <5 kg after gestational diabetes, women with a BMI of ≥30 kg/m² at baseline and who gained ≥5 kg after gestational diabetes had an adjusted HR of 43.19 for type 2 diabetes.
“Baseline BMI, most recent BMI, and weight gain after [gestational diabetes] were significantly and positively associated with risk of progression from [gestational diabetes] to type 2 diabetes,” the researchers wrote.