Although the association between obesity and diabetes is well known, the factors predisposing to diabetes in non-obese Asians are less clearly characterized.

To investigate the effects of impaired insulin secretion (IIS) and insulin resistance (IR) according to BMI on the incidence of diabetes in the Saku Study.

This 4-year cohort study involved 3,083 participants aged 30–69 years without diabetes at baseline (2006–2007). Participants were stratified by BMI. Based on insulinogenic index and homeostasis model of IR values, participants were classified into four categories.

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Results shed some light on the relationship between BMI and development of type 2 diabetes in this patient population.

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