(HealthDay News) — For patients with type 2 diabetes on background glimepiride therapy, but not metformin, addition of ranolazine is associated with a significant reduction in HbA1c, according to research published in Diabetes, Obesity and Metabolism.

Jeremy Pettus, MD, from the University of California, San Diego, and colleagues examined the efficacy of ranolazine for glycemic control in patients with type 2 diabetes on metformin or glimepiride. 

Dr Pettus and colleagues randomly assigned 431 and 442 patients to ranolazine vs placebo added to glimepiride or metformin background therapy, respectively. To correct for the metformin-ranolazine pharmacokinetic interaction, patients receiving ranolazine added to metformin had their metformin dose halved.

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The researchers found that, compared with placebo, the addition of ranolazine to glimepiride was associated with a 0.51% decrease from baseline in HbA1c at 12 weeks, and near doubling of the proportion of patients achieving an HbA1c of less than 7% (27.1% vs 14.1%; P=.001). 

There was no significant difference in the 24-week HbA1c change from baseline when ranolazine was added to metformin background therapy.

“In conclusion, relative to placebo, ranolazine added to glimepiride reduced HbA1c by 0.51%, while combination therapy with metformin did not significantly decrease HbA1c, though this was in the setting of reduced metformin dosing relative to those taking placebo,” the researchers wrote.

Several authors disclosed financial ties to biopharmaceutical companies, including Gilead Sciences, which manufactures ranolazine and funded the research.


  1. Pettus J, McNabb B, Eckel RH, et al. The effect of ranolazine on glycemic control in patients with type 2 diabetes treated with either glimepiride or metformin. Diabetes Obes Metab. 2016;doi:10.1111/dom.12629.