HealthDay News — Young adults with long-standing, childhood-onset type 1 diabetes have increased total and cardiovascular disease (CVD) mortality, according to a study published in Diabetes Care.
Rachel G. Miller, from the University of Pittsburgh, and colleagues studied 502 adults aged younger than 45 years with childhood-onset type 1 diabetes from the Pittsburgh Epidemiology of Diabetes Complications Study during the 1996 to 2012 follow-up. Mortality and CVD rates were calculated for those aged 30 to 39 years and 40 to 44 years.
The researchers found that the standardized mortality ratio (SMR) for total mortality was about 5 in both age groups. CVD mortality SMRs varied from 20 to 33. The hospitalized CVD incidence rate ratio was about 8 for both age groups; much of the increased risk was accounted for by revascularization procedures. The relative risk was larger in women for all outcomes. The absolute 10-year CVD risk for participants aged 30 to 39 years was 6.3%, approaching the cut point of 7.5% for statin initiation in older adults.
“Total and CVD mortality and hospitalized CVD are all significantly increased in this contemporary US cohort of young adults with long-standing type 1 diabetes,” the researchers wrote. “These findings support more aggressive risk factor management in type 1 diabetes, especially among women.”
Disclosures: One researcher provides consulting for Eli Lilly and Profil Institute.
- Miller RG, Mahajan HD, Costacou T, Sekikawa A, Anderson SJ, Orchard TJ. A contemporary estimate of total mortality and cardiovascular disease risk in young adults with type 1 diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study [published online September 21, 2016]. Diabetes Care. doi:10.2337/dc16-1162.