HealthDay News — The risks of ischemic and hemorrhagic stroke are increased with type 1 diabetes, with incrementally increasing risks with increasing HbA1c, according to a study published in the Journal of Internal Medicine.

Christina Hedén Ståhl, from the University of Gothenburg in Sweden, and colleagues conducted a prospective, matched cohort study to examine the excess stroke risk in relation to glycemic control in patients with type 1 diabetes. Patients with type 1 diabetes registered in the Swedish National Diabetes Register (33,453 participants) were each matched to 5 control participants from the general population (159,924 participants).

The researchers found that 2.3% of patients with diabetes and 0.7% of control participants were diagnosed with stroke. Patients with type 1 diabetes had overall multiple-adjusted hazard ratios (HRs) of 3.29 and 2.49 for ischemic and hemorrhagic stroke, respectively, compared with controls. With increasing HbA1c, the risk for ischemic and hemorrhagic stroke increased incrementally; the risk for ischemic stroke was significantly increased with HbA1c within target (≤6.9%, multiple-adjusted HR: 1.89). The risks of ischemic and hemorrhagic stroke were markedly increased for HbA1c ≥9.7%, with multiple-adjusted HRs of 7.94 and 8.17, respectively.

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“Individuals with type 1 diabetes have an increased risk of ischemic and hemorrhagic stroke, increasing markedly with poor glycemic control,” the researchers wrote.

Disclosures: The Novo Nordisk Foundation provided some funding for the study.

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  1. Ståhl CH, Lind M, Svensson A-M, Gudbjörnsdottir S, Mårtensson A, Rosengren A. Glycaemic control and excess risk of ischaemic and haemorrhagic stroke in patients with type 1 diabetes: a cohort study of 33 453 patients [published online December 7, 2016]. J Intern Med. doi:10.1111/joim.12572.