MiniMed Advanced Hybrid Closed-Loop System Leads to Better Glucose Control in T1D

Apparatus for measurig of glucose in the blood on white background. Top view. Copy space
Achieving glycemic control is important in preventing to prevent long-term type 1 diabetes complications. In this featured study, researchers investigate the use of hybrid closed-loop automated basal insulin delivery system.

The use of the MiniMed Advanced Hybrid Closed-Loop (AHCL) system, which features automated correction bolus function and an algorithm comprising individualized basal target set points, was associated with significantly better glucose control than the use of sensor-augmented pump (SAP) therapy with predictive low glucose management (PLGM) in patients with type 1 diabetes (T1D), according to a study in Diabetes Care.

This randomized, open-label study included 59 patients with T1D (mean age, 23.3±14.4 years) who had no history of using an automated insulin-delivery system. The AHCL was compared with SAP + PLGM in terms of glucose control. The study was conducted across 2 intervention periods, with each period lasting 4 weeks and separated by a 2-week washout period. During the preceding run-in period, participants used SAP therapy with low glucose suspend, with the treatment sequence randomized at time of enrollment.

Time spent in target range (TIR) of 3.9 to 10 mmol/L (70–180 mg/dL) favored AHCL compared with SAP + PLGM (70.4±8.1 vs 57.9±11.7) by 12.5±8.5% (P <.001). There was significantly greater improvement in time in target range (TIR) overnight (18.8±12.9%; P <.001). While patients aged 7 to >22 years of age all had improvements, adolescents between 13 and 21 years of age had the largest TIR improvement (14.4±8.4%).

At run-in, the mean sensor glucose (SG) was 9.3±0.9 mmol/L (167±16.2 mg/dL), which and significantly improved with AHCL (8.5±0.7 mmol/L; P <.001) but worsened during PLGM (9.5±1.1 mmol/L; P <.001). An algorithm set point of 5.6 mmol/L (100 mg/dL) vs 6.7 mmol/L (120 mg/dL) resulted in a more optimal TIR (72.0±7.9% vs 64.6±6.9%, respectively).

The Auto Mode was active 96.4±4.0% of the interventions. The percentage time at <3.9 mmol/L (70 mg/dL) during AHCL improved to 2.1±1.4% (70 mg/ dL, P =.034) and was statistically reduced for ≤3.0 mmol/L (0.5±0.5%; P =.025). The investigators observed 1 mild diabetic ketoacidosis episode in the SAP + PLGM arm, which was attributed to an infusion set failure plus an intercurrent illness.

A limitation of this study included its overall short duration, and the investigators suggest a longer follow-up period could confirm if their findings are sustained and lead to additional increases in TIR.

The investigators noted that AHCL with automated corrections represents “an innovation that effectively targets postprandial hyperglycemia by mitigating factors such as carbohydrate underestimation or late/ missed boluses.”

Disclosure: This clinical trial was supported by Medtronic. Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors’ disclosures.


Collyns OJ, Meier RA, Betts ZL, et al. Improved glycemic outcomes with Medtronic MiniMed advanced hybrid closed-loop delivery: Results from a randomized crossover trial comparing automated insulin delivery with predictive low glucose suspend in people with type 1 diabetes. Diabetes Care. 2021;44(4):969-975. doi:10.2337/dc20-2250