Celiac Disease in T1D: International Analysis of Disease Prevalence

HealthDay News — Celiac disease is a common comorbidity in young people with type 1 diabetes, and the prevalence appears to vary internationally, according to a study published online in Diabetes Care.

Maria E. Craig, MBBS, PhD, from the Children’s Hospital at Westmead in Sydney, and colleagues examined international differences in celiac disease prevalence and characteristics of children with coexisting type 1 diabetes and celiac disease versus type 1 diabetes only. Data were included for 52,721 young people aged <18 years.

The researchers found that 3.5% of young people had biopsy-confirmed celiac disease, which was diagnosed at a median age of 8.1 years. The prevalence of celiac disease ranged from 1.9% to 7.7% in the US T1D Exchange Clinic Network and Australasian Diabetes Data Networks, respectively; prevalence was higher for girls than boys (4.3% vs 2.7%; P <.001). Compared to those with type 1 diabetes only, children with coexisting celiac disease were younger at diabetes diagnosis (5.4 vs 7.0 years; P <.001) and fewer were non-white (15% vs 18%; P <.001). Those with celiac disease had lower height standard deviation score (0.36 vs 0.48; adjusted P <.001), and fewer were overweight/obese (34% vs 37%; adjusted P <.001). The mean HbA1c values were comparable (8.3±1.5% vs 8.4±1.6%).

“Differences in celiac disease prevalence may reflect international variation in screening and diagnostic practices, and/or celiac disease risk,” the authors write.

Disclosures: One author disclosed holding an equity fund that may contain stock from pharmaceutical companies.

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Craig ME, Prinz N, Boyle CT, et al; on behalf of the Australasian Diabetes Data Network (ADDN), the T1D Exchange Clinic Network (T1DX), the National Pediatric Diabetes Audit (NPDA), and the Royal College of Paediatrics and Child Health and the Prospective Diabetes Follow-up (DPV) Registry Initiative. Prevalence of celiac disease in 52,721 youth with type 1 diabetes: international comparison across three continents. Diabetes Care. 2017;40(8):1034-1040. doi:10.2337/dc16-2508