(HealthDay News) — Plasma uric acid levels are significantly lower in adolescent patients with type 1 diabetes than in healthy control subjects, and there does not appear to be a link between  levels and cardiorenal abnormalities in these patients, according to a study published in Diabetes Care.

Yuliya Lytvyn, Ph.D., from the University of Toronto, and colleagues evaluated data from 188 participants in the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial and 65 healthy controls. They studied the association between plasma uric acid and estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio, blood pressure, endothelial function, and arterial stiffness.

The researchers found that plasma uric acid was lower in participants with type 1 diabetes than controls. In patients with type 1 diabetes, higher plasma uric acid was inversely associated with eGFR even after adjustment for baseline clinical demographic characteristics. 


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After adjustment for potential confounders, such as eGFR, plasma uric acid was not associated with albumin-to-creatinine ratio in patients with type 1 diabetes. Plasma uric acid levels did not correlate with cardiovascular parameters (systolic blood pressure, flow-mediated dilation, or carotid-femoral pulse wave velocity) in either participants with type 1 diabetes or healthy controls.

“In contrast with adults, in adolescents with type 1 diabetes plasma uric acid may not yet be associated with cardiorenal abnormalities,” the researchers wrote.

Reference

  1. Lytvyn Y, Mahmud FH, Daneman D, et al. Association Between Plasma Uric Acid Levels and Cardiorenal Function in Adolescents With Type 1 Diabetes. Diabetes Care. 2016. doi:10.2337/dc15-2345.