Type 1 Diabetes

Latest News

Preterm Birth May Increase Risk for Type 1 and Type 2 Diabetes

By

Amit Akirov, MD

The risk for type 1 and type 2 diabetes from childhood into adulthood is increased in preterm-born individuals.

Type 1 Diabetes May Increase Progression of Coronary Artery Calcium During Menopause

For women going through menopause, type 1 diabetes is associated with higher coronary artery calcium volume and accelerated progression of CAC over time.

Insulin Glargine 300 U/mL Approved for Pediatric Patients With Diabetes

By

Brian Park, PharmD

The FDA has expanded the indication for Toujeo (insulin glargine; Sanofi) 300 Units/mL to include treatment of pediatric patients aged ≥6 years with diabetes mellitus.

Examining Changes in BMI From Childhood to Puberty in Type 1 Diabetes

By

Amit Akirov, MD

The high prevalence of overweight and obesity in youth with T1D was consistent across a multinational cohort and persistent over time.

Alarm Settings of CGM Systems Affect Glucose Control in T1D

Adjusting glucose thresholds for hypoglycemia and hyperglycemia alarms in continuous glucose monitoring can help achieve better glucose control in patients with type 1 diabetes.

Medicaid Expansion Has a Positive Impact on Diabetes Management

By

Amit Akirov, MD

Medicaid expansion under the Affordable Care Act was found to improve self-reported diabetes management and self-reported health outcomes in patients with type 1 or type 2 diabetes.

Topical Wound Oxygen Therapy Improves Healing of Diabetic Foot Ulcers

By

Amit Akirov, MD

Combination of cyclical pressure Topical Wound Oxygen (TWO2) therapy with optimal standard of care improves healing and can reduce recurrence of diabetic foot ulcer.

Closed-Loop System Better Controls Blood Glucose Than Sensor-Augmented Insulin Pump

By

Amit Akirov, MD

A closed-loop insulin delivery system, also referred to as an artificial pancreas, was found to be more effective than sensor-augmented insulin pump therapy in patients with type 1 diabetes.

Fast-Acting Insulin Approved for Use in Insulin Infusion Pumps

By

Brian Park, PharmD

The FDA has expanded the indication for Fiasp (insulin aspart injection; Novo Nordisk) 100 Units/mL to include use in insulin infusion pumps to improve glycemic control in adults with type 1 or type 2 diabetes.

Glycemic Control Worse Than Previously Thought in Adults With T1D

For adults with type 1 diabetes, glycemic control may be worse than previously thought, and rates of all complications increase with increasing hemoglobin A1c.

Plasma Copeptin Level Linked to Lower-Extremity Amputations in Diabetes

By

Hannah Dellabella

Researchers assessed whether plasma copeptin, a surrogate marker of vasopressin, is associated with lower-extremity amputation in diabetes.

Comparison of Faster vs Standard Insulin Aspart in Fully Closed-Loop Insulin Therapy

By

Amit Akirov, MD

There were no clear benefits of using faster insulin aspart in closed-loop insulin therapy and the closed-loop algorithm was better adjusted to the use of standard insulin aspart.

Aggressive Lowering of HbA1c in T1D Does Not Reduce Eye, Kidney Disease

A glycated hemoglobin (HbA1c) target value of <6.5 percent does not offer additional protection against organ complications for patients with type 1 diabetes compared with a target of 6.5 to 6.9 percent.

Hypoglycemia Risk May Be Lower With Liver-Targeted Rapid-Acting Insulin Formulation

By

Amit Akirov, MD

Hepatic-directed vesicle insulin, a novel liver-targeted rapid-acting insulin formulation for type 1 diabetes, is noninferior to insulin lispro for improvement of HbA1c and is associated with a lower hypoglycemia risk in some patients.

Examining Potential Allergens in Adhesives Used for Diabetes Devices

By

Tyler Rice

Colophonium, a fast-acting adhesive and known sensitizing allergen, may cause dermatologic reactions in children using devices to manage diabetes.

ADO09 Confers Better Glucose Control, Slower Gastric Emptying Than Insulin Lispro in T1D

By

Brandon May

ADO09, a coformulation of amylin analog pramlintide and A21G human insulin, is superior to insulin lispro for reducing postprandial blood glucose in patients with type 1 diabetes.

Use of Insulin Pump Therapy, CGM Increasing in Type 1 Diabetes

Highest rates reported among preschoolers, children, and adolescents aged younger than 15 years

Recommendations for Mealtime Insulin Adjustment According to Dietary Fat Intake

By

Amit Akirov, MD

There is a dose-dependent relationship between the amount of fat and postprandial glucose levels.

Antibody Negativity, Growth, and Metabolic Control in T1D With Celiac Disease

By

Amit Akirov, MD

Researchers found approximately one-third of patients with type 1 diabetes and celiac disease were able to achieve sustained celiac-specific antibody negativity after celiac disease diagnosis.

Type 1 Diabetes Misdiagnosed in One-Fourth of Children, Adults

Type 1 diabetes diagnosis is missed less frequently when patients present during childhood or adolescence, but unlike in adults, misdiagnosis in childhood is associated with an increased likelihood of diabetic ketoacidosis.