(HealthDay News) — For women with gestational diabetes, triglycerides are significantly elevated throughout pregnancy, according to a review published in BJOG: An International Journal of Obstetrics & Gynaecology.

Kelli K. Ryckman, PhD, from the University of Iowa College of Public Health in Iowa City, and colleagues conducted a systematic review and meta-analysis to examine the correlation between lipid measures throughout pregnancy and gestational diabetes. Data from 60 studies were pooled and random effects models were used to calculate the weighted mean difference in lipid levels.

The researchers found that for women with vs. those without gestational diabetes, triglyceride levels were significantly elevated (weighted mean difference, 30.9); this finding was consistent across all trimesters of pregnancy. 

In women with vs. those without gestational diabetes, HDL cholesterol levels were significantly lower in the second and third trimesters of pregnancy (weighted mean difference, –4.6 and –4.1, respectively). 

There were no differences seen in aggregate total cholesterol or LDL cholesterol between women with gestational diabetes and those without insulin resistance.

“Our meta-analysis shows that triglycerides are significantly elevated among women with [gestational diabetes] compared with women without insulin resistance and this finding persists across all three trimesters of pregnancy,” the researchers wrote.

Reference

  1. Ryckman KK et al. BJOG. 2015;doi:10.1111/1471-0528.13261.