HealthDay News — The beneficial effects of intensive systolic blood pressure (SBP) treatment are similar among those with prediabetes and fasting normoglycemia, according to a study published online in Diabetes Care.

Adam P. Bress, PharmD, from the University of Utah in Salt Lake City, and colleagues conducted a post hoc analysis of data from the Systolic Blood Pressure Intervention Trial (SPRINT; identifier NCT01206062). The study assessed the effects of intensive (<120 mmHg) compared with standard (<140 mmHg) SBP treatment among 3898 patients with prediabetes (fasting serum glucose ≥100 mg/dL) vs 5425 patients with fasting normoglycemia (fasting serum glucose <100 mg/dL) at baseline.

The researchers found that over a median 3.26 years of follow-up, the hazard ratio for the primary outcome of composite cardiovascular disease (CVD) outcomes (myocardial infarction [MI], acute coronary syndrome not resulting in MI, stroke, acute decompensated heart failure, or death from CVD causes) was 0.69 (95% CI, 0.53-0.89) among those with prediabetes and 0.83 (95% CI, 0.66-1.03) in those with normoglycemia (P for interaction =.3). The hazard ratio for all-cause mortality with intensive SBP treatment was 0.77 (95% CI, 0.55-1.06) for prediabetes and 0.71 (95% CI, 0.54-0.94) for normoglycemia (P for interaction =.74). The effects of intensive vs standard SBP treatment were not significant for prespecified renal outcomes and serious adverse events.

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“The current SPRINT analysis demonstrates that the beneficial effects of intensive SBP treatment on CVD events and all-cause mortality extend to patients with prediabetes,” the authors write.

Disclosures: Several authors disclosed financial ties to pharmaceutical companies, including Takeda, which provided study medications.


Bress AP, King JB, Kreider KE, et al; for the SPRINT research group. Effect of intensive versus standard blood pressure treatment according to baseline prediabetes status: a post hoc analysis of a randomized trial [published online August 2017]. Diabetes Care. doi:10.2337/dc17-0885