(HealthDay News) — Diagnosis of gestational diabetes early in pregnancy remains associated with poorer pregnancy outcomes, according to a study published in Diabetes Care.

Arianne N. Sweeting, PhD, from the Royal Prince Alfred Hospital in Sydney, and colleagues retrospectively evaluated outcomes for 4873 women attending a university hospital antenatal diabetes clinic between 1991 and 2011. Women were classified as preexisting diabetes (n=65) or gestational diabetes diagnosed at <12 weeks of gestation (n=68), at 12 to 23 weeks of gestation (n=1247), or at ≥24 weeks of gestation (n=3493).

The researchers found that women with preexisting diabetes and early gestational diabetes had a higher prevalence of hypertensive disorders in pregnancy, including preeclampsia, preterm delivery, cesarean section, and neonatal jaundice (all P<.001). 


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Rates of macrosomia (P=.8), large for gestational age (P=.4), and neonatal intensive care admission (P=.9) were comparable in women diagnosed with gestational diabetes at <12 weeks of gestation and women with preexisting diabetes.

“These findings indicate the need for further studies to establish the efficacy of alternative management approaches to improve outcomes in these high-risk pregnancies,” the researchers wrote.

Reference

  1. Sweeting AN, Ross GP, Hyett J, et al. Gestational Diabetes Mellitus in Early Pregnancy: Evidence for Poor Pregnancy Outcomes Despite Treatment. Diabetes Care. 2015;doi:10.2337/dc15-0433.