Post-CABG Stroke Predictors in Diabetes Identified

(HealthDay News) — For patients with diabetes undergoing multivessel coronary artery bypass grafting (CABG), predictors of stroke include previous stroke, warfarin use and surgery outside the United States or Canada, according to research published in The American Journal of Cardiology.

Michael J. Domanski, MD, from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues examined demographic and clinical variables associated with perioperative and late stroke in patients with diabetes after CABG. 

Predictors of stroke after CABG were assessed in patients from the Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease (FREEDOM) randomized trial.

Previous stroke, warfarin use and surgery outside the United States or Canada were independent predictors for perioperative stroke (OR=6.96, 10.26 and 9.81, respectively), according to the data. 

Renal insufficiency (HR=3.57), baseline lLDL ≥105 mg/dL (HR=3.28) and baseline diastolic blood pressure (HR=0.95 for each 1-mm Hg increase) were independent predictors for late stroke. 

No overlap was seen for predictors of perioperative vs. late stroke.

“In conclusion, late post-CABG strokes were associated with well-described risk factors,” the researchers wrote. “Nearly half of the strokes were perioperative. Independent risk factors for perioperative stroke: previous stroke, previous warfarin use, and CABG performed outside the United States or Canada.”


  1. Domanski MJ et al. Am J Cardiol. 2015;115(10):1382-1388.