(HealthDay News) — Plasma prekallikrein is associated with vascular disease risk in type 1 diabetes, according to a study published in Diabetes.

Miran A. Jaffa, PhD, from the University of Beirut, and colleagues measured circulating levels of plasma PK activity in the plasma of 636 participants with type 1 diabetes from the Epidemiology and Diabetes Intervention and Complications (EDIC) cohort (EDIC years 3-5). They measured common and internal carotid intima-media thickness (IMT) in EDIC years 1 and 6.

The researchers observed a positive correlation for plasma PK levels with BMI, HbA1c, systolic blood pressure, total cholesterol, LDL cholesterol, and triglycerides, but not with age, sex, diabetes duration, and HDL cholesterol. 

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There was a consistent correlation between plasma PK and progression of internal carotid IMT in univariate models and multivariable models after adjustment for other risk factors. Plasma PK was significantly associated with progression of both internal and combined IMT in multivariate analysis. 

Compared with those with plasma PK levels in the lower 10th percentile, subjects with plasma PK levels in the highest 10th percentile had higher mean internal carotid IMT levels (P=.048).

“These novel findings implicate plasma PK as a risk factor for vascular disease in type 1 diabetes,” the researchers wrote.


  1. Jaffa MA, Luttrell D, Schmaier AH, et al; for The DCCT/EDIC Research Group. Plasma Prekallikrein is Associated with Carotid Intima-Media Thickness in Type 1 Diabetes. Diabetes. 2015;doi:10.2337/db15-0930.