Gut Microbiomes of Infants with High Risk for Diabetes Differ by Location

Genes Affect Gut Bacteria That Determines Body Weight
Genes Affect Gut Bacteria That Determines Body Weight
Infants at high risk of developing type 1 diabetes have gut microbiomes that vary by geographical location.

OBJECTIVE Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes.

RESULTS Study site-specific patterns of gut colonization share characteristics across continents. Finland and Colorado have a significantly lower bacterial diversity, while Sweden and Washington state are dominated by Bifidobacterium in early life. Bacterial community diversity over time is significantly different by geographical location.

CONCLUSIONS The microbiome of high-risk infants is associated with geographical location. Future studies aiming to identify the microbiome disease phenotype need to carefully consider the geographical origin of subjects.

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