(HealthDay News) — A 2-hour, one-step screening process increases gestational diabetes detection, but has no impact on maternal or neonatal outcomes, according to research published in Clinical Diabetes.

Kisti P. Fuller, MD, from the University of Connecticut John Dempsey Hospital in Farmington, and Adam F. Borgida, MD, from Hartford Hospital in Connecticut, assessed the relative benefits of the two-step (50-g, 1-hour glucose test followed by a 100-g, 3-hour oral glucose tolerance test [OGTT] for those screening positive) and the one-step (75-g, 2-hour test) gestational diabetes screening tests. 

The study was conducted at an inner-city, tertiary-care hospital, which changed its routine from the two-step to the one-step process and included data for 812 patients.

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The researchers found that 458 patients underwent two-step testing (16.4% required OGTT) and 257 patients underwent one-step testing. 

Seven percent of the patients who underwent two-step testing ultimately tested positive for gestational diabetes after OGTT, compared with 11.7% who underwent one-step screening. 

Overall, 9.9% were not compliant with 1-hour screening, compared with 16.4% who were not compliant with 2-hour screening (P=.007). 

No between-group differences were seen for mode of delivery, average birth weight or Apgar score, or in the rates of neonatal outcomes.

“The one-step, 2-hour screening for [gestational diabetes] appears to be associated with an increased rate of [gestational diabetes], despite decreased rates of screening, without improving maternal or neonatal outcomes,” the researchers wrote.


  1. Fuller KP and Borgida AF. Clin Diabetes. 2014;32(4):148-150.