Comparing Glucose Control With Varying Insulin Glargine Doses

HealthDay News — For patients with type 1 diabetes, receipt of insulin glargine 300 U/mL (Gla-300) is associated with better glucose control than glargine 100 U/mL (Gla-100), regardless of injection time, according to a study published online January 23 in Diabetes Care.

Richard M. Bergenstal, MD, from the International Diabetes Center at Park Nicollet in Minneapolis, and colleagues conducted a 16-week trial involving 59 adult patients with type 1 diabetes. Participants were randomized to once-daily Gla-300 or Gla-100 given in the morning or evening in a 1:1:1:1 ratio.

The researchers found that between the Gla-300 and Gla-100 groups, the percentage of time within the target glucose range, as measured using continuous glucose monitoring (CGM), was comparable. The CGM-based glucose increased significantly less during the last four hours of the 24-hour injection interval for Gla-300 versus Gla-100 (least squares mean difference −14.7 mg/dL). 

Irrespective of morning or evening injection, the mean 24-hour glucose curves were smoother for the Gla-300 group. No difference was seen between Gla-300 and Gla-100 in four metrics of intra-subject interstitial glucose variability. 

Gla-300 participants had lower nocturnal confirmed or severe hypoglycemia rate than for Gla-100 participants (4.0 versus 9.0 events per participant-year, rate ratio, 0.45).

“Less increase in CGM-based glucose levels in the last four hours of the 24-hour injection interval, smoother average 24-hour glucose profiles irrespective of injection time, and reduced nocturnal hypoglycemia were observed with Gla-300 versus Gla-100,” the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Sanofi, which funded the study.


Bergenstal RM, Bailey TS, Rodbard D, et al. Comparison of insulin glargine 300 U/mL and 100 U/mL in adults with type 1 diabetes: Continuous glucose monitoring profiles and variability using morning or evening injections.[published online January 23, 2017] Diabetes Care. doi: 10.2337/dc16-0684

This article originally appeared on MPR