(HealthDay News) — Early intervention with vitamin D in deficient individuals may help ward off early onset of insulin resistance, according to a study published in Diabetes, Obesity and Metabolism.

Sigal Tepper, PhD, from Ben-Gurion University in Beer-Sheva, Israel, and colleagues randomly assigned 130 men without diabetes (average age, 47.52 years) who had 25-hydroxyvitamin D (25[OH]D) serum levels lower than 20 ng/mL to treatment (100 000 IU vitamin D bimonthly) or placebo.

The researchers found, after adjusting for baseline levels, age, BMI, sun exposure, physical activity, and LDL holesterol, that there were significant differences in insulin and homoeostasis model assessment of insulin resistance (HOMA-IR) between groups. In the treatment group, levels of insulin and HOMA-IR remained steady, but they increased by 16% in the control group (P=.038 and .048, respectively).

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“Further studies are needed to establish the long-term effect of vitamin D supplementation on the risk of diabetes,” the researchers wrote.


  1. Tepper S, Shahar DR, Geva D, Ish-Shalom S. Differences in HOMA and insulin levels following vitamin D supplementation in healthy† men: A randomized double blind controlled trial. Diabetes Obes Metab. 2016. doi:10.1111/dom.12650.