(HealthDay News) — Statin treatment is associated with reduced risk for incident cataract development, according to a study published in The American Journal of Cardiology.
Casper N Bang, MD, PhD, from the Weill Cornell Medical College in New York City, and colleagues randomly assigned 1873 patients with asymptomatic aortic stenosis and no history of diabetes, coronary heart disease, or other comorbidities to simvastatin 40 mg plus ezetimibe 10 mg or placebo.
The researchers found that 3.5% of patients developed incident cataract during an average follow-up of 4.3 years. Simvastatin plus ezetimibe correlated with a reduction in the risk for cataract development compared with placebo, after adjustment for age, gender, prednisolone treatment, smoking, baseline LDL cholesterol, and high sensitivity C-reactive protein (hazard ratio [HR]=0.56; P=.034).
Lower in-treatment LDL cholesterol correlated with a reduced risk for incident cataract (HR=0.78 per 1 mmol/mL lower total cholesterol; P=.008), in a parallel analysis substituting time-varying LDL cholesterol with randomized treatment.
“Randomized treatment with simvastatin plus ezetimibe was associated with a 44% lower risk of incident cataract development,” the researchers wrote. “This effect should perhaps be considered in the risk-benefit ratio of statin treatment.”
Disclosure: Several authors disclosed financial ties to pharmaceutical companies, including Merck, which manufactures simvastatin and ezetimibe and provided funding for the study.
- Bang CN, Greve AM, La Cour M, et al. Effect of Randomized Lipid Lowering With Simvastatin and Ezetimibe on Cataract Development (from the Simvastatin and Ezetimibe in Aortic Stenosis Study). Am J Cardiol. 2015;116(12):1840-1844.