(HealthDay News) — Combinations of pregnancy complications can predict high risk for cardiovascular disease (CVD) death, according to a study published in Circulation.

Piera M. Cirillo, MPH, and Barbara A. Cohn, PhD, from the Public Health Institute in Berkeley, California, and colleagues examined pregnancy events (1959 to 1967) and subsequent CVD death in 14,062 women from the Child Health and Development Studies. 

The women were a median age of 26 years at enrollment and were followed through 2011 (median age, 66 years).

CVD death was predicted by preexisting hypertension, glycosuria, late-onset preeclampsia (after week 34) and hemoglobin decline over the second and third trimesters (HRs=3.5, 4.2, 2.0 and 1.7, respectively), the researchers found. 

Premature CVD death was significantly predicted by delivery of a small-for-gestation or preterm infant and early onset preeclampsia by week 34 (P<.05 for age dependence). 

The combination of preterm birth with hemorrhage, gestational hypertension or preexisting hypertension correlated with a four- to seven-fold elevated CVD death risk. The risk was nearly six-fold for preeclampsia in conjunction with preexisting hypertension, compared with a four-fold risk for preexisting hypertension alone.

“Obstetricians serve as primary care physicians for many young women and can readily use these complications to identify high-risk women to implement early prevention,” the researchers wrote.


  1. Cirillo PM, Cohn BA. Circulation. 2015;doi:10.1161/CIRCULATIONAHA.113.003901.