(HealthDay News) — For patients with pulmonary hypertension associated with heart failure and preserved ejection fraction (PH-HFpEF), the 6-minute walk distance test can independently predict outcomes, according to a study published in JACC: Heart Failure.
Caroline Zotter-Tufaro, from the Medical University of Vienna, and colleagues examined the prognostic significance and clinical determinants of the 6-minute walk distance test. Data were included for 142 patients with PH-HFpEF, as confirmed by right heart catheter.
The researchers found that 30.3% of patients reached the combined end point of hospitalization for heart failure and/or death for cardiac reasons after a mean follow-up of 14.0 months. The 6-minute walk distance test independently predicted outcome and was affected by clinical, echocardiographic, hemodynamic, laboratory and pulmonary parameters.
The 6-minute walk distance test and the extent of extracellular matrix in the left ventricular myocardium were significantly inversely correlated.
“Impaired exercise capacity in PH-HFpEF patients is explained by cardiac and noncardiac factors,” the researchers wrote. “The [6-minute walk distance] predicts outcome and may be a useful end point in clinical trials.”