(HealthDay News) — Patients with severe mental illness have increased mortality after myocardial infarction (MI), according to a study published in the Journal of Internal Medicine.

Robert Bodén, MD, PhD, from Uppsala University in Sweden, and colleagues examined the impact of severe mental illness on MI survival in a population-based cohort study. Data were included for all 209,592 patients with a first diagnosis of MI in the Swedish nationwide MI register from 1997 to 2010. 

Exposure was defined as a diagnosis of severe mental illness (i.e., bipolar disorder or schizophrenia) prior to infarction.

The 442 patients with bipolar disorder and 541 with schizophrenia were younger than those without severe mental illness (mean age, 68 and 63 years, respectively, vs. 71 years). 

The overall 30-day mortality rate was 10% and the 1-year mortality rate was 18%. In the fully adjusted model, patients with severe mental illness had elevated 30-day mortality and 1-year mortality (ORs=1.99 and 2.11, respectively) compared with patients without severe mental illness. Patients with schizophrenia had the highest mortality (ORs=2.58 and 2.55 for 30-day and 1-year mortality, respectively).

“[Severe mental illness] is associated with a marked higher mortality after myocardial infarction, even after accounting for contributing factors,” the researchers wrote. “It is imperative to identify the reasons for this higher mortality.”


  1. Bodén R et al. J Intern Med. 2014;doi:10.1111/joim.12329.