ODYSSEY MONO: Alirocumab Effective For Lowering LDL Cholesterol

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PCSK9 inhibitor beat ezetimibe for lowering LDL cholesterol in phase 3 trial.

Alirocumab is a fully human monoclonal antibody to PCSK9. The ODYSSEY MONO study was the first alirocumab phase 3 study to test a previously unused dose of 75 mg subcutaneously every 2 weeks in a population on no lipid-lowering therapy. 

A total of 103 patients were randomly assigned to alirocumab starting at 75 mg subcutaneously every 2 weeks or ezetimibe 10 mg per os every day with alirocumab dose uptitration at 12 weeks based on achieved LDL-cholesterol level at week 8 and followed to week 24.

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