(HealthDay News) — A low-salt diet further improves the efficacy of antihypertensive drug regimens, according to a study published in the Journal of Clinical Pharmacology.

Jing Zhuang, from The Second Affiliated Hospital of Chongqing Medical University in China, and colleagues randomly assigned 180 patients with mild to moderate primary hypertension to a low-salt diet (2.3 g sodium per day) group or a non-low-salt diet group. 

Each group included three antihypertensive drug regimens: losartan 100 mg; losartan 50 mg/hydrochlorothiazide 12.5 mg; or irbesartan 150 mg/hydrochlorothiazide 12.5 mg.

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The researchers found that after 2 months of follow-up, there were significant reductions in office blood pressure (BP), 24-hour mean BP and morning BP in both groups (P≤.01). 

Among the three low-salt diet subgroups there were no significant differences, according to the data. The losartan 50 mg/hydrochlorothiazide 12.5 mg and the irbesartan 150 mg/hydrochlorothiazide 12.5 mg subgroups showed similar antihypertensive efficacy in the non-low-salt diet group, with significant reductions in BP compared with the losartan 100 mg group. 

Patients in the low-salt diet group had significant BP reductions compared with the non-low-salt diet group.

“We concluded that this [low-salt diet] exerts synergistic BP-reducing effects,” the researchers wrote.


  1. Zhuang J et al. J Clin Pharmacol. 2015;doi:10.1002/jcph.559.