Impact of Changes in HbA1c, BMI Changes on Lipids Increases as Children Age

HealthDay News — As children age, the impact of changes in HbA1c and BMI on LDL cholesterol and non-HDL cholesterol levels increases, according to a study published in Diabetes Care.

Michelle L. Katz, MD, MPH, from the Joslin Diabetes Center in Boston, and colleagues conducted a dynamic, retrospective study examining changes in lipid values in 572 young people with type 1 diabetes followed longitudinally for a median of 9.3 years. After adjustment for other relevant factors, the relationship between HbA1c and BMI z score (zBMI) on lipid values was described as participants aged.

The researchers found that each 1% increase in HbA1c correlated with a 2 to 6 mg/dL increase in LDL levels; as subjects progressed from pre- to postpubertal age ranges the increase was greater. When subjects were 10 years old, a 1 standard deviation increase in BMI correlated with a mean LDL increase of 2.1 mg/dL, compared with a mean increase of 8.2 mg/dL when subjects were 19 years old. Similar correlations were seen for HbA1c level and zBMI changes and variation in non-HDL levels. A small influence was seen for HBA1c and zBMI on HDL levels, which was not dependent on age.

“Changes in HbA1c level and zBMI modestly impact LDL and non-HDL cholesterol and have greater impacts as children age,” the researchers wrote.

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  1. Katz ML, Kollman CR, Dougher CE, Mubasher M, Laffel LMB. Influence of HbA1c and BMI on lipid trajectories in youths and young adults with type 1 diabetes. Diabetes Care. 2016 Oct 20. doi:10.2337/dc16-0430.