(HealthDay News) — For patients after first-time myocardial infarction, inflammatory bowel disease is associated with worse prognosis, according to a study published in Circulation: Cardiovascular Quality and Outcomes.

Søren Lund Kristensen, MD, PhD, from the Copenhagen University Hospital Gentofte in Denmark, and colleagues examined the effect of active inflammatory bowel disease (IBD) on the outcomes of 86,790 patients after myocardial infarction (MI). Of these, 1,030 patients had IBD, and their disease was categorized as flare, persistent activity or remission.

Compared with the non-IBD group, the odds ratio for death during hospitalization or within 30 days of discharge was 3.29 (95% CI, 1.98-5.45) for patients with IBD flares, 1.62 for persistent activity (95% CI, 0.95-2.77) and 0.97 for remission (95% CI, 0.78-1.19).

Among the patients alive 30 days after discharge, IBD correlated with hazard ratios (HRs) of 1.21 (95% CI, 0.99-1.49) for recurrent MI, 1.14 (95% CI, 1.01-1.28) for all-cause mortality and 1.17 for the composite end point (recurrent MI, cardiovascular death and stroke; 95%CI, 1.03-1.34).

IBD flares were associated with increased risks for recurrent MI, all-cause mortality and the composite end point (HRs=3.09, 2.25 and 2.04) compared with the non-IBD group, but there was no increased risk seen in remission.

“Active inflammatory bowel disease worsens prognosis after MI, in particular, in relation with flares,” the researchers wrote.

One author was supported by a scholarship from the Novo Nordisk Foundation.

Reference

  1. Kristensen SL et al. Circ Cardiovasc Qual Outcomes. 2014;doi:10.1161/CIRCOUTCOMES.114.000918.