(HealthDay News) — For patients with chronic liver disease, statin initiation is associated with low overall incidence of hospitalization due to severe hepatic injury, according to a study published in the Journal of Gastroenterology and Hepatology.

Chia-Hsuin Chang, MD, PhD, from the National Taiwan University in Dou-Liou City, and colleagues conducted a nationwide population-based cohort study involving 37,929 subjects with chronic liver disease who started statin therapy. 

The researchers estimated the risk for severe hepatic injury associated with different statins; hospitalization due to liver injury was used as the outcome measure.

The researchers identified 912 incident cases of hospitalization due to hepatic injury during a total of 118,772 person-years of follow-up. For atorvastatin, lovastatin, fluvastatin, pravastatin, simvastatin and rosuvastatin initiators, the incidence rates were 2.95, 2.49, 2.92, 1.94, 2.65 and 2.52 per 100,000 person-days, respectively.

There was no difference overall in the incidence with different statins. On further categorization of high- and low-dose statins, high-dose, but not low-dose, atorvastatin was significantly associated with increased risk of hospitalization due to hepatic injury (HR=1.62; 95% CI, 1.29-2.03).

“The overall incidence of hospitalization due to severe hepatic injury was low among statin initiators with chronic liver disease,” the researchers wrote.


  1. Chang CH et al. J Gastroenterol Hepatol. 2014;doi:10.1111/jgh.12657.