(HealthDay News) — Genetically determined vitamin K1 is associated with coronary artery disease (CAD) and myocardial infarction (MI), according to a study published in the Journal of Thrombosis and Haemostasis.

C. Mary Schooling, PhD, from the CUNY School of Public Health in New York City, assessed the risk of CAD/MI according to genetically determined vitamin K1 levels. She used separate sample instrumental variable analysis with genetic instruments to obtain an unconfounded estimate of the correlation of vitamin K1 with CAD/MI using CARDIoGRAMplusC4D (64 374 cases and 130 681 controls) and with lipids using Global Lipids Genetics Consortium Results (196 475 individuals).

Schooling observed a positive association for vitamin K1 single nucleotide polymorphisms with CAD/MI (odds ratio [OR]=1.17 per unit [nmol/L] of natural log-transformed genetically predicted vitamin K1), but not with inverse normal transformed LDL cholesterol, HDL cholesterol, or triglycerides. The association for CAD/MI was stronger considering only rs2108622, which is functionally relevant to vitamin K1 (OR=1.21).

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“Vitamin K may cause CAD/MI, whether vitamin K or other determinants of coagulants could be relevant to primary prevention might bear consideration,” Schooling wrote.


  1. Schooling CM. Plasma levels of vitamin K and the risk of ischemic heart disease: a Mendelian randomization study. J Thromb Haemost. 2016. doi:10.1111/jth.13332.