(HealthDay News) — Genetically determined vitamin K1 is associated with coronary artery disease (CAD) and myocardial infarction (MI), according to a study published in the Journal of Thrombosis and Haemostasis.
C. Mary Schooling, PhD, from the CUNY School of Public Health in New York City, assessed the risk of CAD/MI according to genetically determined vitamin K1 levels. She used separate sample instrumental variable analysis with genetic instruments to obtain an unconfounded estimate of the correlation of vitamin K1 with CAD/MI using CARDIoGRAMplusC4D (64 374 cases and 130 681 controls) and with lipids using Global Lipids Genetics Consortium Results (196 475 individuals).
Schooling observed a positive association for vitamin K1 single nucleotide polymorphisms with CAD/MI (odds ratio [OR]=1.17 per unit [nmol/L] of natural log-transformed genetically predicted vitamin K1), but not with inverse normal transformed LDL cholesterol, HDL cholesterol, or triglycerides. The association for CAD/MI was stronger considering only rs2108622, which is functionally relevant to vitamin K1 (OR=1.21).
“Vitamin K may cause CAD/MI, whether vitamin K or other determinants of coagulants could be relevant to primary prevention might bear consideration,” Schooling wrote.