Cardiovascular and Metabolic Disorders

Latest News

Subclinical Cardiac Pathology Common in Women With HIV

By

Amit Akirov, MD

In women with ART-treated HIV, there is a 3-fold increase in intramyocardial triglyceride content and reduced diastolic function, leading to higher CVD risk.

Bempedoic Acid Plus Ezetimibe Lowers LDL-C When Added to Maximally Tolerated Statin Therapy

By

Endocrinology Advisor Contributing Writer

Fixed-dose bempedoic acid with ezetimibe lowered LDL-C vs placebo when added to maximally tolerated statin therapy in patients with high CVD risk and hypercholesterolemia.

Hypertensive Disorders of Pregnancy Predict Postpartum Dysglycemia

By

Hannah Dellabella

Women with hypertensive disorders of pregnancy had higher postpartum fasting plasma glucose levels and approximately double the risk for newly diagnosed type 2 diabetes.

Statin Discontinuation Linked to CV Admissions in Elderly Patients

For elderly patients taking statins for primary prevention, statin discontinuation is associated with an increased risk for admission for any cardiovascular event.

Evinacumab Effective in Homozygous Familial Hypercholesterolemia Trial

By

Diana Ernst, RPh

Results from a phase 3 trial evaluating the efficacy of evinacumab (Regeneron) in the treatment of patients with homozygous familial hypercholesterolemia (HoFH) showed that the investigational angiopoietin-like 3 (ANGPTL3) antibody reduced low-density lipoprotein (LDL) cholesterol by 49%.

Variability of BMI, HDL-C in Childhood May Predict Risk for Diabetes in Adulthood

By

Hannah Dellabella

Increased variations of body mass index and high-density lipoprotein cholesterol during childhood are independent risk factors for the development of diabetes.

High-Intensity Lipid Lowering May Benefit Very Elderly Patients After ACS

Benefit of simvastatin-ezetimibe combo after acute coronary syndrome greatest for patients ≥75 years

Moderate Caloric Restriction Can Improve CV Risk in Healthy Patients

By

Amit Akirov, MD

Moderate caloric restriction for 2 years may improve several cardiovascular risk factors in young and middle-aged healthy individuals.

Preventing Progression to ASCVD and T2D: An Endocrine Society Guideline

By

Rachael Beairsto

The Endocrine Society published a clinical practice guideline cosponsored by the American Diabetes Association and the European Society of Endocrinology regarding the primary prevention of ASCVD and T2D.

The “Good Cholesterol” Myth of HDL: Update and Interview

By

Tori Rodriquez, MA, LPC, AHC

Although high-density lipoprotein cholesterol has been deemed the “good cholesterol,” this label may be misleading and outdated given that there is little evidence to support a causal relationship with CVD risk reduction.

FDA Recalls Herbal Medications Being Marketed for Various Diseases

By

Steve Duffy

In addition to being manufactured outside of the controls required by current Good Manufacturing Practices, these products are also being marketed for diseases without FDA approval.