Familial hypercholesterolemia is one of the most clinically relevant monogenic disorders contributing to the development of atherosclerotic cardiovascular disease.
Bempedoic acid is a first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers LDL-C by inhibiting cholesterol synthesis in the liver.
The increased mortality rate in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy is mostly related to endocrine and metabolic diseases, infections, and oral and esophageal malignancies.
Treatment with statins is not associated with increased risk for ICH in patients with a history of stroke, and may even decrease the risk for ICH in some of these patients.
Among other strategies, clinicians can suggest changes to lifestyle habits, encourage sleep hygiene, and prescribe pharmacologic interventions to combat risk for metabolic syndrome in shift workers.
Machine learning identifies factors related to obesity, dyslipidemia, and inflammation as predictors of noncalcified coronary burden in patients with psoriasis, a study finds.
While current cardiovascular risk scores can identify subclinical vascular damage in people living with HIV, they fail to predict progression of such damage.
Dapagliflozin was found to lower the risk for worsening heart failure or death in patients with heart failure and reduced ejection fraction, and with or without diabetes compared with placebo.
