Sclerostin Increase After Bariatric Surgery Results in Bone Loss

Primary Hyperparathyroidism Screening Needs Improvement
Primary Hyperparathyroidism Screening Needs Improvement
Increases in sclerostin and other bone turnover markers after bariatric surgery results in bone loss.

Context: The role of sclerostin as a key regulator of bone formation remains unknown after Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (SG).

Objectives:Evaluation of sclerostin and Dickkopf-1 (DKK-1) serum levels after surgery and correlations with bone turnover markers (P1NP, CTX), parathyroid hormone (iPTH) and areal bone mineral density (BMD), changes at total body, lumbar spine and total hip.

Design and Setting: A prospective observational single-center two-arm study in premenopausal women with acute adipositas over 24 months.

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