(HealthDay News) — Higher monthly doses of vitamin D have no benefit on lower extremity function and correlate with increased risk for falls compared with lower doses in elderly adults, according to a study published in JAMA Internal Medicine.

Heike A. Bischoff-Ferrari, MD, DrPH, from the University Hospital Zurich, and colleagues examined the effectiveness of high-dose vitamin D in lowering the risk for functional decline in 200 community-dwelling men and women aged 70 years and older with a prior fall. Participants were allocated to 3 study groups with monthly treatments: 24 000 IU vitamin D3 (low-dose control group), 60 000 IU vitamin D3, and 24 000 IU vitamin D3 plus 300 mcg calcifediol.

The researchers observed no significant difference between the groups in terms of improving lower extremity function (P=.26). 

The incidence of falls differed significantly between the groups over the 12-month follow-up, with higher incidences in the 60 000 IU group and the 24 000 IU plus calcifediol group vs the 24 000 IU group (66.9% and 66.1%, respectively, vs 47.9%; P=.048). The mean number of falls was higher for the 60 000 IU group and the 24 000 IU plus calcifediol group vs the 24 000 IU group (mean, 1.47 and 1.24, respectively, vs 0.94; P=.09).

“High monthly doses of vitamin D or a combination with calcifediol may not be warranted in seniors with a prior fall,” the researchers wrote.

One author disclosed financial ties to pharmaceutical and nutrition companies, including Merck Sharp & Dohme, WILD, and DSM Nutritional Products, which funded the study.


  1. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, et al. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2015;doi:10.1001/jamainternmed.2015.7148.