(HealthDay News) — Urolithiasis patients may be at increased risk for fractures and may require treatment to protect their bone health, according to a new study published in the Clinical Journal of the American Society of Nephrology.

Researchers led by Michelle Denburg, MD, of the Children’s Hospital of Philadelphia, analyzed data from 51,785 British urolithiasis patients and 517,267 people without urolithiasis.

During a median follow-up of nearly 5 years, urolithiasis patients were found to be at significantly higher risk for fractures, and this increased risk affected all bones, Denburg’s team found. 

Overall, males with urolithiasis were 10% more likely to suffer broken bones than those without urolithiasis. The risk was highest among male teens — those with urolithiasis had a 55% higher risk for fractures than those without the condition. 

Among women, those with urolithiasis had a 17% to 52% increased risk for fractures from their 20s to their 60s, with the highest risk among women aged 30 to 39 years.

The findings only point to an association between urolithiasis and fracture risk, and do not prove a cause-and-effect relationship. However, the researchers believe that efforts to boost urolithiasis patients’ bone health might help shield them from fractures.

“Given that the median time from diagnosis of urolithiasis to fracture was a decade, we might be able to intervene during this interval to reduce the burden of future fracture,” Denburg said in a news release from the American Society of Nephrology.


  1. Denburg MR et al. Clin J Am Soc Nephrol. 2014;doi:10.2215/​CJN.04340514.