(HealthDay News) — Diet-induced weight loss is associated with a decrease in total hip, but not lumbar spine, bone mineral density (BMD), according to a review published in the Journal of Bone and Mineral Research.

Jessica Zibellini, from the University of Sydney, and colleagues conducted a systematic review and meta-analysis to quantify the effect of diet-induced weight loss on bone. Data were included from 41 publications involving overweight or obese but otherwise healthy adults.

Of six, 12 and 24 months’ duration, diet-induced weight loss correlated with significant decreases of 0.010 g/cm² to 0.015 g/cm² in total hip BMD, according to the data. For interventions of 3 to 24 months’ duration, there was no significant effect of diet-induced weight loss on lumbar spine or whole body BMD, although there was a significant decrease in total body BMD after 6 months (−0.011 g/cm²). 

There was no significant change in serum concentrations of N-terminal propeptide of type I procollagen; significant increases were seen in serum concentrations of osteocalcin, C-terminal telopeptide of type I collagen and N-terminal telopeptide of type I collagen with interventions of 2 or 3 months in duration.

“These data show that in overweight and obese individuals, a single diet-induced weight loss intervention induces a small decrease in total hip BMD, but not lumbar spine BMD,” the researchers wrote.

One author disclosed financial ties to the pharmaceutical industry.


  1. Zibellini J et al. J Bone Miner Res. 2015;doi: 10.1002/jbmr.2564.