(HealthDay News) — An intervention including cholecalciferol, protein supplementation and physical exercise reduces bone mineral density loss after bariatric surgery, according to a study published in the Journal of Bone and Mineral Research.

Christian Muschitz, MD, from the Medical University of Vienna, and colleagues conducted a prospective study involving 220 women and men after Roux-en-Y gastric bypass and sleeve gastrectomy procedures. Participants were randomly assigned to an intervention group (cholecalciferol before and after surgery, protein supplementation and physical exercise) or a nonintervention group.

There were differences in the intervention and nonintervention groups with respect to the relative percentage changes of serum levels of sclerostin (12.1% vs. 63.8%), cross-linked C-telopeptide (82.6% vs. 158.3%), 25-hydroxyvitamin D (13.4% vs. 18.2%), phosphate (23.7% vs. 32%; all P<.001), procollagen type 1 amino-terminal propeptide (12% vs. 41.2%), intact parathyroid hormone (−17.3% vs. −7.6%), and Dickkopf-1 (−3.9% vs. −8.9%; all P<.05). 

The intervention group had less pronounced, but significant, decline in lumbar spine, total hip and total body areal bone mineral density (aBMD) as well as changes in BMI, lean body mass and Trabecular Bone Score (P<.005 for all).

Vitamin D loading and ongoing vitamin D, calcium, and BMI-adjusted protein supplementation in combination with physical exercise decelerates the loss of aBMD and [lean body mass] after bariatric surgery,” the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.


  1. Muschitz C et al. J Bone Miner Res. 2015;doi:10.1002/jbmr.2707.