(HealthDay News) – For premenopausal women with breast cancer, chemotherapy plus the luteinizing hormone-releasing hormone analogue (LHRHa) triptorelin is associated with higher long-term probability of ovarian function recovery, according to a study published in the Journal of the American Medical Association.

Matteo Lambertini, MD, from the Istituto Nazionale per la Ricerca sul Cancro in Genova, Italy, and colleagues examined the long-term results of LHRHa-induced ovarian suppression during breast cancer chemotherapy. Two hundred eighty-one premenopausal women with stage I to III hormone-receptor positive or hormone-receptor negative breast cancer were enrolled and randomized to chemotherapy plus LHRHa (148 patients) or chemotherapy alone (control; 133 patients). Participants were followed for a median of 7.3 years.

The researchers found that the 5-year cumulative incidence estimate of menstrual resumption was 72.6% in the LHRHa group and 64.0% in the control group (hazard ratio [HR], 1.28; 95% confidence interval [CI], 0.98 to 1.68; P=0.07; age-adjusted HR, 1.48; 95% CI, 1.12 to 1.95; P=0.006). The 5-year cumulative incidence of pregnancy was 2.1% and 1.6% in the LHRHa and control groups, respectively (HR, 2.56; 95% CI, 0.68 to 9.60; P=0.14; age-adjusted HR, 2.40; 95% CI, 0.62 to 9.22; P=0.20).

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“Concurrent administration of triptorelin and chemotherapy, compared with chemotherapy alone, was associated with higher long-term probability of ovarian function recovery, without a statistically significant difference in pregnancy rate,” the authors write.


Lambertini M, Boni L, Michelotti A, et al. Ovarian Suppression with Triptorelin During Adjuvant Breast Cancer Chemotherapy and Long-term Ovarian Function, Pregnancies, and Disease-free Survival: A Randomized Clinical Trial. JAMA. 2015;314(24):2632-2640. doi:10.1001/jama.2015.17291.