HealthDay News — Maternal exposure to perfluoroalkyl substances (PFAS) is associated with higher odds of late-onset preeclampsia, according to a study published in the October issue of Environmental Health Perspectives.

Paige A. Bommarito, Ph.D., from the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina, and colleagues examined associations between PFAS and any preeclampsia diagnosis using data from 75 cases and 75 controls identified from the LIFECODES birth cohort. Nine PFAS were measured from samples collected at a median 10 weeks of gestation.

The researchers found that both perfluorodecanoic acid (odds ratio [OR], 1.64) and perfluorooctanesulfonic acid (OR, 1.60) were associated with higher odds of late-onset preeclampsia. The associations were not significant for early-onset preeclampsia. Few associations were noted between PFAS and angiogenic biomarkers.


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“The main goal of this article was to try to provide information for scientists that are looking to do similar studies,” a coauthor said in a statement. “Replicating and validating these results can help inform us about how toxicants like PFAS impact maternal health, hopefully leading to relevant policy changes.”

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