Managing Opioid-Induced Androgen Deficiency
The increased opioid use has been associated with a rising incidence of opioid-induced endocrinopathy, most commonly in the form of androgen deficiency.
Hypogonadism
HYPOGONADISM
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Suboptimal Screening for Hypogonadism in Men Receiving Opioids
More men with long-term opioid use are screened for low testosterone than men taking opioids for a short period of time; however, given the known link between opioid use and low testosterone, these rates were still lower than expected.
Testosterone Undecanoate May Reduce CV Morbidity, Mortality in Men With Hypogonadism, Type 2 Diabetes
Long-term treatment with testosterone undecanoate was associated with reduced cardiovascular morbidity and mortality in patients with hypogonadism and type 2 diabetes.
Genetically Determined Low Vitamin D Concentrations Associated With Low Testosterone Levels
Genetically low 25-hydroxyvitamin D levels are associated with lower testosterone levels.
Testosterone Deficiencies Common in Men With Hepatitis C Virus Infection
In a subanalysis, researchers discovered that testosterone deficiency was common in men with a sustained virologic response after being treated for hepatitis C.
Testosterone Replacement in Congenital Hypogonadotropic Hypogonadism Has Limited Effects on Bone Health
Testosterone replacement therapy prevents further bone loss at the lumbar and femoral levels in patients with congenital hypogonadotropic hypogonadism, but it does not reliably elevate bone mineral density out of the osteopenic/osteoporotic range.
New Oral Treatment Approved for Men With Certain Types of Hypogonadism
The Food and Drug Administration (FDA) has approved Jatenzo (testosterone undecanoate; Clarus Therapeutics) capsules for testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone: congenital or acquired primary hypogonadism or hypogonadotropic hypogonadism.
Testosterone Therapy Prevents Progression From Prediabetes to T2D in Hypogonadism
Men with prediabetes, hypogonadism achieved normal glucose regulation with TTh
Testosterone Use Remains High Among Men With Coronary Artery Disease
Despite research suggesting that there may be increased cardiovascular risk from off-label prescription testosterone use, usage in men with coronary artery disease remains higher than in men without coronary artery disease.
New Testosterone Replacement Therapy Approved for At-Home Self-Administration
Xyosted carries a Boxed Warning regarding blood pressure increases that may potentially increase the risk for major adverse cardiovascular events.
Testosterone Levels Increased in Third Trimester Pregnancy in PCOS
Investigators examine total testosterone, free testosterone, and sex hormone binding globulin levels in pregnant women in the third trimester with PCOS.
Low Testosterone Linked With Social Anxiety in Boys With Klinefelter Syndrome
This finding suggests that clinicians should monitor anxiety among individuals with testosterone deficiency and XXY.
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