Hyperandrogenism Linked to Low BMI in Polycystic Ovary Syndrome

Objective: To assess dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) levels in relation to body mass index (BMI) in PCOS.

Results: Obese PCOS patients presented significantly more insulin resistance than non-obese PCOS patients. The LH levels and LH/FSH ratio were significantly higher in low-BMI than in high-BMI PCOS patients. The A₄ and DHEAS levels were significantly higher in non-obese than in obese PCOS patients. A significant correlation between LH and A₄ in non-obese PCOS patients was observed. The frequency of hyperandrogenism by increased A₄, and DHEA along with DHEAS was significantly higher in low-BMI PCOS patients compared to high-BMI PCOS patients. Some findings observed with the BMI cutoff value of 27 kg/m² changed with the cutoff value of 30 kg/m².

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