“In conclusion, we report here for the first time that [menopausal hormone therapy] is associated with better preservation of bone microarchitecture, as assessed by [trabecular bone score],” the researchers wrote.1 “In addition to the well-established positive effect of [menopausal hormone therapy] on BMD, the bone microarchitecture preservation probably contributes to the antifracture efficacy. The protective effect of [menopausal hormone therapy] on BMD and [trabecular bone score] seems to persist after its withdrawal for at least 2 years.”

The researchers noted several study limitations, including self-reporting of data on the start and end of hormone therapy, as well as its route of administration.1 Moreover, the dose of estrogen per participant could not be determined.1

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“Women at menopause should take note of this study, because its results can help optimize the use of menopausal hormone treatment in women at risk of osteoporosis,” Dr Papadakis said.5

Disclosures: Didier Hans is co-owner of the TBS patent and has corresponding ownership shares. The other researchers report no financial disclosures.


  1. Papadakis G, Hans D, Gonzalez-Rodriguez E, et al. The benefit of menopausal hormone therapy on bone density and microarchitecture persists after its withdrawal. J Clin Endocrinol Metab. 2016 Nov 17. doi:10.1210/jc.2016-2695 [Epub ahead of print].
  2. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288:321-333. doi:10.1001/jama.288.3.321.
  3. Anderson GL, Limacher M, Assaf, AR, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA. 2004;291:1701-1712. doi:10.1001/jama.291.14.1701.
  4. Roehm E. A reappraisal of Women’s Health Initiative Estrogen-Alone Trial: long-term outcomes in women 50–59 years of age. Obstet Gynecol Int. 2015;2015:7132955.
  5. Menopausal hormone therapy improves bone health [press release]. Washington, DC: Endocrine Society News Room; November 17, 2016. https://www.endocrine.org/news-room/current-press-releases/menopausal-hormone-therapy-improves-bone-health. Accessed November 21, 2016.