Plasma levels of the orexigenic neuropeptide agouti-related protein (AgRP) are elevated in Cushing disease, and it may be a marker of hypothalamic AgRP.
Results from this single-arm, open-label study found that 30% of patients achieved normalization of mean urinary free cortisol (UFC) after 6 months of maintenance treatment with levoketoconazole, without a dose increase (P<.25).
Study assessed cardiovascular function, quality of life, and mental/physical health in overt and cured Cushing syndrome.
The analysis led to the identification of 4 potentially pathogenic missense variants in CABLES1.
Four-month-old developed iatrogenic Cushing’s syndrome after 6 weeks of intranasal dexamethasone ophthalmic solution.
The etiology of Cushing’s syndrome affects how long it takes for a patient to recover their adrenal function after surgery.
Patients with adrenal tumors of intermediate phenotype or subclinical Cushing’s syndrome are at increased risk of cardiovascular events and mortality compared to those with stable non-secreting adrenal incidentalomas.
A mutation in the PRKACA gene appears to contribute to a rare but severe form of Cushing’s syndrome.
Patients with Cushing’s syndrome who were administered oral mifepristone (Korlym) daily experienced significant, sustained weight loss over the years as they continued on the medication.