Cushing Syndrome

CUSHING SYNDROME

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Cushing Syndrome in Pregnancy: When to Suspect and How to Treat

Despite the preponderance of CS in women of childbearing age and the likelihood of pregnancy triggering CS, the condition is often overlooked because of the overlap of pregnancy and hypercortisolism symptoms.

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Signs and Symptoms of Adrenal Medullary Hyperplasia vs Pheochromocytoma

Hannah Dellabella

Patients with AMH without pheochromocytoma had milder symptoms compared with patients with pheochromocytoma only.

Mifepristone an Effective Alternative to Surgery for Patients With Bilateral Macronodular Adrenal Hyperplasia

Tyler Rice

Mifepristone may be an effective alternative to adrenalectomy in patients with hypercortisolism caused by primary bilateral macronodular adrenal hyperplasia.

Transsphenoidal Surgery Recommended for Cushing Disease With Inconclusive or Normal MRI

Amit Akirov, MD

In the absence of clear evidence of a pituitary adenoma on imaging, there is some controversy regarding the best treatment for Cushing disease.

High Prevalence of Diabetes in Patients With Primary Aldosteronism

Endocrinology Advisor Contributing Writer

Prevalence of diabetes is higher in patients with primary aldosteronism and was found to be related to suspected subclinical hypercortisolism.

New Data for Potential Cushing Syndrome Treatment Levoketoconazole Announced

Da Hee Han, PharmD

Researchers reported that mean urinary-free cortisol (mUFC) normalization with Recorlev was similar in patients with and without diabetes.

Elevated Plasma Agouti-Related Protein May Be a Marker for Cushing Disease

Roxanne Nelson, BSN, RN

Plasma levels of the orexigenic neuropeptide agouti-related protein (AgRP) are elevated in Cushing disease, and it may be a marker of hypothalamic AgRP.

Positive Results for Recorlev in Phase 3 Cushing Syndrome Trial

Results from this single-arm, open-label study found that 30% of patients achieved normalization of mean urinary free cortisol (UFC) after 6 months of maintenance treatment with levoketoconazole, without a dose increase (P<.25).

Cardiovascular Function May Improve After Cure of Cushing Syndrome

Virginia A. Schad, PharmD, RPh

Study assessed cardiovascular function, quality of life, and mental/physical health in overt and cured Cushing syndrome.

New Research Highlights Possible Genetic Cause of Cushing’s Disease

Brian Ellis

The analysis led to the identification of 4 potentially pathogenic missense variants in CABLES1.

Case Report Describes Cushing’s Syndrome in Infant Treated With Ophthalmic Steroid

Four-month-old developed iatrogenic Cushing’s syndrome after 6 weeks of intranasal dexamethasone ophthalmic solution.

Cushing’s Syndrome Etiology Affects Adrenal Function Recovery

The etiology of Cushing’s syndrome affects how long it takes for a patient to recover their adrenal function after surgery.

Cushing Syndrome

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