Adrenal

Latest News

Mifepristone an Effective Alternative to Surgery for Patients With Bilateral Macronodular Adrenal Hyperplasia

By

Tyler Rice

Mifepristone may be an effective alternative to adrenalectomy in patients with hypercortisolism caused by primary bilateral macronodular adrenal hyperplasia.

Hypertension Associated With Glucocorticoid Sensitivity and Activity in Women Without Hypercortisolism

By

Amit Akirov, MD

Hypertension may be associated with degree of glucocorticoid suppression and peripheral activation in postmenopausal women.

Transsphenoidal Surgery Recommended for Cushing Disease With Inconclusive or Normal MRI

By

Amit Akirov, MD

In the absence of clear evidence of a pituitary adenoma on imaging, there is some controversy regarding the best treatment for Cushing disease.

High Prevalence of Diabetes in Patients With Primary Aldosteronism

By

Endocrinology Advisor Contributing Writer

Prevalence of diabetes is higher in patients with primary aldosteronism and was found to be related to suspected subclinical hypercortisolism.

Levoketoconazole Improves Biochemical and Clinical Parameters in Patients With Cushing Syndrome

By

Amit Akirov, MD

Biochemical markers and clinical signs and symptoms of endogenous Cushing syndrome improved after 6 months of levoketoconazole therapy.

Cortisol Pumps May Be Viable Option to Reduce Adrenal Crisis in Severe Adrenal Insufficiency

By

Amit Akirov, MD

The use of insulin pump to deliver continuous pulsatile cortisol may be a viable treatment option in patients with severe adrenal insufficiency who are unresponsive to oral corticosteroids.

Gestational Age, Birth Weight Cutoff Values May Improve Diagnosis of Congenital Adrenal Hyperplasia

By

Amit Akirov, MD

Adjusting threshold levels of 17-OHP to reflect gestational age and birth weight might be a safe and efficient strategy to improve screening for CAH in newborns.

New Data for Potential Cushing Syndrome Treatment Levoketoconazole Announced

By

Da Hee Han, PharmD

Researchers reported that mean urinary-free cortisol (mUFC) normalization with Recorlev was similar in patients with and without diabetes.

Elevated Plasma Agouti-Related Protein May Be a Marker for Cushing Disease

By

Roxanne Nelson, BSN, RN

Plasma levels of the orexigenic neuropeptide agouti-related protein (AgRP) are elevated in Cushing disease, and it may be a marker of hypothalamic AgRP.

High Early-Morning Cortisol Related to Impaired Memory, Lower Brain Volume

By

Brandon May

Researchers investigated a link between higher levels of the stress hormone cortisol and deficient memory skills in people without dementia.

Clinical Indicators of Risk for Addison Disease in Patients With T1D

By

Roxanne Nelson, BSN, RN

Treatment of thyroid disease, severe infections, glucagon prescriptions, and diabetic retinopathy occur more frequently in individuals with type 1 diabetes who are subsequently diagnosed with Addison disease.