Adrenal

Latest News

Increase in HDL-C, Adiponectin Levels With Glucocorticoid Replacement Therapy

By

Amit Akirov, MD

Glucocorticoid replacement therapy is associated with an increase in serum levels of adiponectin and high-density lipoprotein cholesterol.

Additional Cortisol Testing During Low-Dose ACTH Stimulation Test Can Reduce False Positives

By

Hannah Dellabella

Measuring cortisol levels at 15 and 60 minutes in addition to the standard 30 minutes can reduce false positives in standard low-dose ACTH stimulation testing with cosyntropin.

Recovery of HPA Axis Can Occur Late After Transsphenoidal Adenomectomy

By

Amit Akirov, MD

Clinicians should periodically assess patients after transsphenoidal adenomectomy given that recovery of the hypothalamus-pituitary-adrenal axis can occur as late as 12 months postsurgery.

Signs and Symptoms of Adrenal Medullary Hyperplasia vs Pheochromocytoma

By

Hannah Dellabella

Patients with AMH without pheochromocytoma had milder symptoms compared with patients with pheochromocytoma only.

Adrenal Incidentalomas Rarely Grow, Change Hormone Function

Nonfunctioning adrenal tumors (NFATs) or adenomas causing mild autonomous cortisol excess (MACE) rarely show clinically relevant changes in size or hormone function.

Mifepristone an Effective Alternative to Surgery for Patients With Bilateral Macronodular Adrenal Hyperplasia

By

Tyler Rice

Mifepristone may be an effective alternative to adrenalectomy in patients with hypercortisolism caused by primary bilateral macronodular adrenal hyperplasia.

Hypertension Associated With Glucocorticoid Sensitivity and Activity in Women Without Hypercortisolism

By

Amit Akirov, MD

Hypertension may be associated with degree of glucocorticoid suppression and peripheral activation in postmenopausal women.

Transsphenoidal Surgery Recommended for Cushing Disease With Inconclusive or Normal MRI

By

Amit Akirov, MD

In the absence of clear evidence of a pituitary adenoma on imaging, there is some controversy regarding the best treatment for Cushing disease.

High Prevalence of Diabetes in Patients With Primary Aldosteronism

By

Endocrinology Advisor Contributing Writer

Prevalence of diabetes is higher in patients with primary aldosteronism and was found to be related to suspected subclinical hypercortisolism.

Levoketoconazole Improves Biochemical and Clinical Parameters in Patients With Cushing Syndrome

By

Amit Akirov, MD

Biochemical markers and clinical signs and symptoms of endogenous Cushing syndrome improved after 6 months of levoketoconazole therapy.

Cortisol Pumps May Be Viable Option to Reduce Adrenal Crisis in Severe Adrenal Insufficiency

By

Amit Akirov, MD

The use of insulin pump to deliver continuous pulsatile cortisol may be a viable treatment option in patients with severe adrenal insufficiency who are unresponsive to oral corticosteroids.