Adrenal

Latest News

Primary Adrenal Insufficiency Management Is Aided by Genetic Diagnosis

By

Lauren Biscaldi

A team of researchers conducted genetic analyses of children and adolescents with primary adrenal insufficiency of unknown etiology to provide insight into diagnosing this and other related conditions.

Osilodrostat Improves Signs and Symptoms Associated With Cushing Disease

By

Endocrinology Advisor Contributing Writer

A team of investigators conducted a phase 3, multicenter study with a double-blind, randomized withdrawal period to assess the effects of twice-daily osilodrostat in patients with Cushing disease.

Obesity Associated With Worse Outcomes in Patients With Adrenal Insufficiency

By

Endocrinology Advisor Contributing Writer

A team of investigators reviewed data from the 2018 Nationwide Inpatient Sample to assess the impact of obesity on outcomes in patients hospitalized for adrenal insufficiency.

Investigational Gene Therapy Fast Tracked for Congenital Adrenal Hyperplasia

By

Brian Park, PharmD

BBP-631 is an adeno-associated virus 5 (AAV5) gene therapy designed to deliver a functional copy of the 21-hydroxylase gene to restore the body’s ability to produce cortisol and aldosterone.

Oral Corticosteroid Dose Management With Impaired Adrenal Function Evaluated

By

Lauren Biscaldi

Patients with normal adrenal function are largely able to eliminate the use of oral corticosteroids or achieve a daily dose of 5 mg or less.

Half of All Patients With Hypertension Should be Screened for Primary Aldosteronism

By

Amy Reyes

Patients with resistant hypertension and hypokalemia are likely to have primary aldosteronism, which may be at the root of their condition. Screening rates patients for primary aldosteronism doesn’t appear to be common practice.

Genetic Basis for PMAH Enables Earlier Diagnosis, Improves Management of Cushing Syndrome

By

Endocrinology Advisor Contributing Writer

Several research studies presented at ENDO 2021 have evaluated the molecular mechanisms underlying Cushing syndrome to facilitate earlier diagnosis and improve disease management.

Adrenal Insufficiency Associated With Increased CVD and Cerebrovascular Disease

By

Jessica Nye, PhD

Cardiovascular disease is the leading cause of death in patients with adrenal insufficiency. In this study, UK researchers weighed the presence of comorbidities against cardiovascular morbidity and mortality.

11-Hydroxytestosterone Stratifies Patients With Congenital Adrenal Hyperplasia

By

Jessica Nye, PhD

The goal of this study was to evaluate 11-oxyandrogens in discriminating good vs poor disease control in 21OHD in the setting of discrepant 17OHP and A4.

Primary Aldosteronism Testing Rare in Treatment-Resistant HTN

Patients with apparent treatment-resistant hypertension are rarely tested for primary aldosteronism.

Hydrocortisone in Granule Form Effectively Treats Childhood Adrenal Insufficiency

By

Brandon May

Hydrocortisone granules delivered accurate drug dosing to effectively treat pediatric adrenal insufficiency.