Despite the preponderance of CS in women of childbearing age and the likelihood of pregnancy triggering CS, the condition is often overlooked because of the overlap of pregnancy and hypercortisolism symptoms.
Adjusting threshold levels of 17-OHP to reflect gestational age and birth weight might be a safe and efficient strategy to improve screening for CAH in newborns.
Plasma levels of the orexigenic neuropeptide agouti-related protein (AgRP) are elevated in Cushing disease, and it may be a marker of hypothalamic AgRP.
Results from this single-arm, open-label study found that 30% of patients achieved normalization of mean urinary free cortisol (UFC) after 6 months of maintenance treatment with levoketoconazole, without a dose increase (P<.25).
Azedra should be used by or under the control of physicians who are qualified by specific training and experience in the safe use and handling of radiopharmaceuticals.
