Hypovitaminosis D Associated With High 24-Hour Ambulatory BP in T2D

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Researchers examined 24-hour and ambulatory blood pressure to determine the relationship between hypertension and low levels of vitamin D.

Patients with type 2 diabetes and hypertension may also have deficient levels of vitamin D, according to research presented at ENDO 2017: the 99th Annual Meeting & Expo, April 1-4, in Orlando, Florida.

Researchers from the Hospital de Clinicas de Porto Alegre in Brazil conducted a cross-sectional study to evaluate factors that may be associated with vitamin D deficiency in type 2 diabetes with hypertension.

Office blood pressure, 24-hour ambulatory blood pressure, and physical activity were monitored in 116 patients (mean age, 65±8.9 years; 43% men; body mass index, 30.3±4.1 kg/m2) with a diabetes duration of 12.3±8.3 years.

At baseline, mean 25(OH)D was 20.1±9.1 ng/mL; 43% of patients were classified as vitamin D deficient.

In-office measurements of systolic and diastolic blood pressure were 150.7±20.9 mm Hg and 83.5±11.0 mm Hg, respectively. After ambulatory blood pressure monitoring, patients with vitamin D deficiency had higher systolic blood pressure during both the 24-hour monitoring period and the daytime vs those with sufficient levels of vitamin D (135.7±10.2 vs 130.2±13.3 mm Hg; P =.016 and 138.1±11.3 vs 132.8±13.4 mm Hg; P =.026, respectively).

These patients also had lower step counts (4350.0 vs 6390.6 steps per day). Fat mass was not associated with vitamin D deficiency.

“Hypovitaminosis D is highly prevalent in patients with type 2 diabetes and hypertension,” the researchers concluded. “[V]itamin D deficiency was associated with higher BP levels [as well as] less physical activity.” 

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Sperb LF, de Paula TP, Moreira JSR, et al. Vitamin D deficiency is associated with high blood pressure in 24-h ambulatory blood pressure monitoring in patients with type 2 diabetes. Presented at: ENDO 2017: the 99th Annual Meeting & Expo; April 1-4, 2017; Orlando, FL. Abstract MON 640.