Hormone Replacement Therapies

Hormone Replacement Therapies
HORMONE REPLACEMENT THERAPIES
Generic Brand Strength Form Dosing
Frequency
ORAL ESTROGEN
conjugated estrogens Premarin 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg tabs Once daily
esterified estrogens Menest 0.3mg, 0.625mg, 1.25mg, 2.5mg tabs
estradiol (micronized) Estrace 0.5mg, 1mg, 2mg tabs
TRANSDERMAL ESTROGEN
estradiol Alora 0.025mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day transdermal system Twice weekly
Climara 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.06mg/day, 0.075mg/day, 0.1mg/day transdermal system Once weekly
Divigel 0.25mg/pkt, 0.5mg/pkt, 0.75mg/pkt, 1mg/pkt, 1.25mg/pkt topical gel Once daily
Elestrin 0.87g/pump topical gel Once daily
Estrogel 1.25g/pump topical gel 1 pump once daily
Evamist 1.53mg/spray transdermal spray Initially 1 spray daily; may increase to 2−3 sprays if needed
Menostar 14mcg/day transdermal system Once weekly
Minivelle 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day trans
dermal system
Twice weekly
Vivelle-Dot 0.025mg/day, 0.0375mg/day, 0.05mg/day, 0.075mg/day, 0.1mg/day transdermal system Twice weekly
VAGINAL ESTROGEN
conjugated estrogens Premarin 0.625mg/g cream Once daily or twice weekly, cyclically*
estradiol Estring 7.5mcg/24hrs ring Once every 90 days
Femring 0.05mg/day, 0.1mg/day ring Once every 3mos
Imvexxy 4mcg, 10mcg vaginal inserts Initially 4mcg once daily for 2wks, then twice weekly every 3–4 days
Vagifem 10mcg vaginal inserts Once daily for 2wks, then twice weekly
ORAL ESTROGEN + ESTROGEN AGONIST/ANTAGONIST
conjugated estrogens/
bazedoxifene
Duavee 0.45mg/20mg tabs Once daily
ORAL PROGESTOGEN
medroxyprogesterone acetate Provera 2.5mg, 5mg, 10mg tabs Once daily
norethindrone acetate 5mg tabs
progesterone (micronized) Prometrium 100mg, 200mg caps
ORAL ESTROGEN + PROGESTOGEN
conjugated estrogens (14 tabs); then conjugated estrogens/
MPA (14 tabs)
Premphase 0.625mg; then 0.625mg/5mg tabs Once daily, sequentially
conjugated estrogens/
MPA (28 tabs)
Prempro 0.3mg/1.5mg, 0.45mg/1.5mg,
0.625mg/
 
2.5mg, 0.625mg/5mg
tabs Once daily
estradiol/
drospirenone
Angeliq 0.5mg/0.25mg, 1mg/0.5mg tabs Once daily
estradiol/
norethindrone acetate
Activella 0.5mg/0.1mg, 1mg/0.5mg tabs Once daily
estradiol/
progesterone
Bijuva 0.5mg/100mg, 1mg/100mg caps Initially 0.5mg/100mg once daily in PM; adjust based on response
norethindrone acetate/
ethinyl estradiol
0.5mg/2.5mcg, 1mg/5mcg tabs Once daily
Note: Progestin listed first
TRANSDERMAL ESTROGEN + PROGESTOGEN
estradiol/
levonorgestrel
Climara Pro 0.045mg/
 
0.015mg per
 
day
transdermal system Once weekly
estradiol/
norethindrone acetate
Combipatch 0.05mg/
 
0.14mg per
 
day,
0.05mg/
 
0.25mg per
 
day
transdermal system Twice weekly
NOTES

*Once daily for atrophic vaginitis or kraurosis vulvae. Twice weekly for dyspareunia.

Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. Estrogen component is listed first for combination products. Listed strengths are not necessarily the same as the dosage. Listed dosing frequency is for use in HRT; may be other frequencies for other uses. Some products are given cyclically.

(Rev. 4/2022)

This article originally appeared on MPR